2025年3月30日 · IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include Dyskeratosis Congenita, Autosomal Dominant 6 and Leprosy. Among its related pathways are Akt Signaling and Interleukin-12 family signaling.

白细胞介素-12 (IL-12)是由两个独立基因IL-12A (p35)和IL-12B (p40)编码的一种多效能细胞因子，它们以一种活性异源二聚体(p70)或p40的同型二聚体(p80)形式存在，主要由抗原刺激的树突状细胞、巨噬细胞和中性粒细胞产生，其受体由IL12RB1和IL12RB2组成。

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. [5] . IL12RB2 orthologs [6] have been identified in all mammals for which complete genome data are available.

该蛋白和 IL12RB1 蛋白的共表达显示导致高亲和力 IL12 结合位点的形成和 IL12 依赖性信号传导的重建。 该基因的表达在 Th1 细胞中被干扰素γ上调，并在 Th1 细胞分化中发挥作用。 该基因的上调被发现与许多传染病有关，例如克罗恩病和麻风病，这被认为有助于炎症反应和宿主防御。 已发现该基因的几种编码不同亚型和非蛋白质编码转录物的转录物变体。 [RefSeq 提供，2012 年 4 月] The protein encoded by this gene is a type I transmembrane protein identified as a subunit of …

IL12RB2 is a prognostic marker in Head and neck squamous cell carcinoma, Kidney renal papillary cell carcinoma

Estrogen receptor beta 2 regulates IL12RB2 expression via p38 MAPK signaling and inhibits non-small-cell lung cancer proliferation and invasion. IL12RB2 polymorphism is associated with systemic lupus erythematosus in the Chinese population. Genetic variations of IL-12B, IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.

2025年1月4日 · IL12RB2 interleukin 12 receptor subunit beta 2 Gene ID: 3595, updated on 4-Jan-2025 Gene type: protein coding. See all available tests in GTR for this gene; Go to complete Gene record for IL12RB2; Go to Variation Viewer for IL12RB2 variants; Summary

2024年9月18日 · Title: An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

2020年12月22日 · When expressed in COS-7 cells, IL12RB2 exists as a disulfide-linked oligomer with an apparent monomeric molecular mass of 130 kD. Functional studies indicated that high affinity IL12R is composed of at least 2 beta-type cytokine receptor subunits, each independently exhibiting low affinity for IL12.

IL12RB2是1号染色体的基因。 该基因编码的蛋白是一种I型跨膜蛋白，被鉴定为 白细胞介素 12受体复合物的一个亚单位。 该蛋白与IL12RB1蛋白的共表达导致IL 12高亲和力结合位点的形成和IL 12依赖信号的重建。 该基因在 Th1细胞 中的表达受γ干扰素的上调，在Th1细胞的分化中起着重要作用。 该基因的上调与许多传染病有关，如 克罗恩病 和麻风病，这些疾病被认为有助于炎症反应和宿主防御。 已经发现了几个编码不同异构体和非蛋白编码转录本的转录体。 [ …