2024年12月25日 · IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include Inflammatory Bowel Disease 28, Autosomal Recessive and Inflammatory Bowel Disease 28. Among its related …

Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease. IL10R signaling regulates TH17 polarization and T-cell proliferation in humans but is not required for the generation and in vitro suppression of Tregs.

2014年9月4日 · By generating mice lacking Il10 or Il10ra in Cx3cr1 (601470)-expressing macrophages residing in intestinal lamina propria, Zigmond et al. (2014) found that Il10 was dispensable for gut homeostasis and maintenance of colonic regulatory T cells.

Loss-of-function mutations in IL10, IL10RA, or IL10RB genes are the cause of severe phenotypes of infantile IBD. Of 267 patients with detailed genetic reports, 91 unique mutations at the DNA level were identified.

By screening a Burkitt lymphoma cell cDNA library using transfection and panning with COS-7 cells and tagged IL10 (124092), Liu et al. (1994) isolated IL10RA, which they called IL10R. The deduced 578-amino acid protein has signal peptide, extracellular domain, transmembrane domain, and cytoplasmic domain and a calculated molecular mass of 61 kD.

2022年4月27日 · Loss-of-function mutations in IL10, IL10RA, or IL10RB genes are the cause of severe phenotypes of infantile IBD. Of 267 patients with detailed genetic reports, 91 unique mutations at the DNA level were identified.

We systematically investigated the prevalence, structural, and functional consequences of pathogenic IL10RA variants that are associated with monogenic inflammatory bowel disease. We identify 36 non-synonymous and non-sense variants in the IL10RA gene.

IL-10 receptor 1 (IL-10R1, also referred to as IL-10Rα) is an ~80,000 kDa protein with an extracellular ligand binding domain (ECD) of 227 residues, a transmembrane helix of 21 residues, and an intracellular domain (ICD) of 322 amino acids.

5 天之前 · The STAT3 binding site (SBS) of IL10RA mutated cell line was generated using CRISPR/Cas9 genome editing by electroporation of CRISPR/Cas9 elements into the human Jurkat T cells, as previously described. 55, 56 The sequences of the two sgRNAs targeting the STAT3 binding site of IL10RA gene was shown in Table S2. Mutated cells were obtained using ...

2024年3月1日 · It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3 …