While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts …

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been …

Interleukin-5 (IL-5) is a cytokine that is primarily produced by activated CD4+ helper T cells, mast cells, and eosinophils. It is responsible for stimulating the functions of eosinophils, which are a …

2024年5月16日 · We present the cryo-EM structure of the human IL-5 ternary receptor complex, revealing architectural principles for IL-5, GM-CSF, and IL-3. In mammalian cell culture, single …

IL-5 critically regulates expression of genes involved in proliferation, cell survival and maturation and effector functions of B cells and eosinophils. Thus, IL-5 plays a pivotal role in innate and …

IL-5 is a 45 kDa glycoprotein consisting of two identical polypeptide chains. The 5'-promoter region of the IL-5 gene contains elements that are down-regulated by glucocorticoids. Anti-IL-5 …

1994年1月1日 · The chapter summarizes advances in interleukin-5 (IL-5) and IL-soluble receptor (IL-SR) research in the study of structure, physiologic functions, and the unique modes of …

This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM …

2022年1月1日 · Interleukin (IL)-5 is a cytokine dimer derived from both hematopoietic and non-hematopoietic cell lines that primarily contribute to the proliferation, differentiation, and survival …

2012年1月15日 · IL-5 is involved in a number of immune responses such as helminth infection and allergy. IL-5 also plays roles in innate immunity by maintaining B-1 B cells and mucosal …