Feb 5, 2025 · Here we show that expression of a CTL signature is strongly associated with IL27 expression in human and mouse tumours. In mice, IL-27 acts directly on tumour-specific CTLs …

Interleukin-27 (IL27) is a recently discovered cytokine belonging to the IL6/IL12 cytokine family [1]. Due to the heterodimeric nature of these cytokines and their receptors, studies on the IL12 family members have generated exciting stories to follow.

IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8 + T cells, promotes the development of Tfh and Tr1, and suppresses the …

Interleukin-27 (IL-27), a member of the IL-6/IL-12 family, has diverse regulatory functions in various immune responses, and is recognised as a potent agonist and antagonist of CD4+T cells in different contexts.

Dec 12, 2012 · Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the Epstein-Barr virus-induced gene 3 (EBi3) and IL-27p28, which engages a receptor composed of gp130 and the IL-27Rα that activates Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and mitogen activated protein kinase (MAPK) signaling (see Figure 1) (Kastel...

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to …

Dec 14, 2012 · Here we provide an overview of the immunobiology of IL-27 and review advances in understanding the functions of individual IL-27 and IL-27 receptor subunits and the role of IL-27 in dictating the balance between protective and pathological immunity.

Our data demonstrate that endogenous IL-27 is essential for anti-tumour immunity and that IL-27 receptor agonism can safely improve anti-tumour T cell responses alone or in combination with PD-L1 blockade.

Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection, cell stress, neuronal disease, and tumors. Recent studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in innate and acquired immunity.

Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presenting cells and plays an important role in the regulation of CD4+ T cell differentiation and immune response. IL-27 activates multiple signaling cascades, including the JAK-STAT and p38 MAPK pathways.