TP53
2024年3月1日 · An analysis of single nucleotide polymorphisms in the sequencing results revealed that in the p53-R175H group, the nucleotide at position chr17:7675088 (GRCh38.p14) was changed from C to T. To visually confirm the success of ZR-75-1 cells transfected with the TP53 R175H variant, we performed IGV visualization analysis (Fig. 4 a).
转录组入门4-参考基因组、注释文件下载及IGV - 知乎
在UCSC下载hg19参考基因组，我博客有详细说明，从gencode数据库下载基因注释文件，并且用IGV去查看你感兴趣的基因的结构，比如TP53,KRAS,EGFR等等。 作业：
p53 immunostaining pattern is a useful surrogate marker for TP53 …
In the present study, we investigated the association between TP53 gene mutations and p53 immunohistochemical staining (IHC) patterns and non-genetic effect of MDM2 as a negative regulator of p53.
Genomic complexity and IGHV mutational status are key …
The great majority (86%) of patients with 17p disruption by CN-arrays (either 17p loss or CNN-LOH) also had concurrent TP53 mutations. Among patients with de novo TP53 disruption, 21 of 30 (70%) required CLL-specific therapy (Online Supplementary Table S4).
转录组入门（4）：了解参考基因组及基因注释 - 简书
2017年7月12日 · 在UCSC下载hg19参考基因组，我博客有详细说明，从gencode数据库下载基因注释文件，并且用IGV去查看你感兴趣的基因的结构，比如TP53,KRAS,EGFR等等。 作业，截图几个基因的IGV可视化结构！
IGHV and TP53 Sequencing: Clinical Utility in Chronic ... - Insights
2019年8月12日 · Our goals today are, first of all, to understand the use of prognostic markers in CLL patients; second, to highlight the importance of molecular analyses for IGHV and TP53 sequencing in CLL patients; third, to understand how IGHV mutation analysis provides prognostic information in CLL and can help inform clinicians about possible treatment ...
Relationship between p53 dysfunction, CD38 expression, and
2002年8月15日 · Established adverse prognostic factors in chronic lymphocytic leukemia (CLL) include CD38 expression, relative lack of IgVH mutation, and defects of the TP53 gene.
TP53 and IGHV Continue to Demonstrate Utility as Predictive Markers …
2021年10月23日 · In a debate, experts discuss the importance of IGHV and TP53 mutational status in predicting response to novel therapies in chronic lymphocytic leukemia.
Snapshot of IGV showing TP53 mutation (p.R174X) in GBM_9 …
Download scientific diagram | Snapshot of IGV showing TP53 mutation (p.R174X) in GBM_9 and its matched blood sample. MuTect filtered out this mutation because three reads supporting the variant...
【转录组入门】4：参考基因组和注释文件 - 微凉charles - 博客园
2018年6月30日 · Integrative Genomics Viewer (IGV)是一种探索大型综合基因组数据的高性能交互式可视化工具。 它支持各种各样的数据类型，包括基于芯片测序、二代测序数据和基因组注释数据等。 1 # 进入IGV官网，并下载相应的软件包，有Windows，Mac，和LINUX，这里我下载Linux二进制包. 2 $ cd ~/ src. 3 $ wget http: //data.broadinstitute.org/igv/projects/downloads/IGV_2.3.97.zip 4 $ unzip IGV_2. 3.97. zip && …