2019年12月15日 · (D) CD31 modulation after IgG stimulation was assessed in monocytes stimulated with either plate-bound IgG or ΔIgG (n = 3). (E) CD31 surface expression was analyzed in PBM after plate-bound IgG stimulation for 24 h by flow cytometry (n = 7).

CD31又称为血小板-内皮细胞黏附分子（Platelet endothelial cell adhesion molecule-1 ，PECAM-1/CD31），分子量为130kDa，其结构属于免疫球蛋白超家族成员，在清除体内老化的中性粒细胞过程中发挥重要作用。

2019年12月15日 · Monocytes and macrophages express FcγR that engage IgG immune complexes such as Ab-opsonized pathogens or cancer cells to destroy them by various mechanisms, including phagocytosis. FcγR-mediated phagocytosis is regulated by the concerted actions of activating FcγR and inhibitory receptors, such as …

The 390 monoclonal antibody specifically binds to CD31, also known as PECAM-1 (platelet endothelial cell adhesion molecule). CD31 is a ~130 kDa integral membrane glycoprotein, a member of the immunoglobulin superfamily, that mediates …

2016年6月27日 · Here, we examined Ig secretion of distinct rhesus CD138+ populations by B cell ELISpot analysis to couple phenotype with function. We demonstrate that the CD20low/−CD138+CD31+ BM population was highly enriched for antibody-secreting cells with IgG being the predominant isotype (60%), followed by IgA (33%) and IgM (7%).

CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1).

2019年12月15日 · Scr or CD31 siRNA-nucleofected cells were incubated in control PBS-treated (UT, untreated) or plate-bound IgG for 24 h, and supernatants were analyzed for cytokine content using a bead array as described in Materials and Methods (n = 7).