Mar 30, 2025 · Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral …

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene. [4] [5] [6]

IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. You might find these chapters and articles …

Jun 5, 2011 · Nature Immunology - The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a...

Oct 1, 2014 · IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. IFIT1 preferentially recognizes …

IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/beta-catenin signaling. Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by …

IFIT proteins (Interferon Induced proteins with tetratricopeptide repeats) are produced in the human body and are supposed to confer immunity against viral infections.

Dec 14, 2012 · This report showed that IFIT1 binds to the free 5′-ppp moiety on viral RNA from vesicular stomatitis virus, Rift Valley fever virus and influenza A virus and inhibits their …

Jan 16, 2025 · The Ifit1 gene is a key component in the body’s defense against viral infections, playing a role in innate immunity as an early responder to pathogenic threats. Understanding …

In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-α) response in macrophages, we identify the interferon-stimulated protein IFIT1 as a …