2025年3月30日 · Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral …

IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. You might find these chapters and articles …

2011年6月5日 · Nature Immunology - The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a...

2014年10月1日 · IFIT1 is an IFN-induced highly expressed protein that functions in the cytoplasm as a dual sensor and effector molecule to restrict virus infection. IFIT1 preferentially …

IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/beta-catenin signaling. Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by …

This review focuses on the recent cellular, biochemical, and structural discoveries that have provided new insight as to how IFIT1 functions as both a sensor and effector molecule of the …

2012年12月14日 · This report showed that IFIT1 binds to the free 5′-ppp moiety on viral RNA from vesicular stomatitis virus, Rift Valley fever virus and influenza A virus and inhibits their …

2025年1月16日 · The Ifit1 gene is a key component in the body’s defense against viral infections, playing a role in innate immunity as an early responder to pathogenic threats. Understanding …

Previously considered an antiviral protein, IFIT1 is identified as a reciprocal modulator of bacterially induced pro-inflammatory and interferon genes and shown to associate with …

2018年10月2日 · In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-α) response in macrophages, we identify the interferon …