IDRA-21是种 AMPA受体 （ 英语 ： AMPA receptor ） 的 正別構調節劑 （ 英语 ： Allosteric modulator ） ，也是 苯丙噻二嗪 （ 英语 ： Benzothiadiazine ） 的衍生物，也是一种手性分子，(+)-IDRA-21是其活性形式。

IDRA-21 is a positive allosteric modulator of the AMPA receptor and a benzothiadiazine derivative. It is a chiral molecule, with (+)-IDRA-21 being the active form. [1] IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory.

2025年3月27日 · IDRA-21 is a potent nootropic in the world of smart drugs that’s known for its cognitive-enhancing effects. It’s often used to improve memory, focus, and learning. IDRA-21 is considered to be safe if used as directed, although it has not been FDA-approved for …

2004年6月1日 · IDRA-21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) reduces α-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptors desensitisation in vitro and restores learning and cognitive impairment in vivo.

2004年1月1日 · IDRA 21, a positive allosteric modulator of the glutamate AMPA receptor, produced a concentration-dependent inhibition of glutamate-induced inactivation of membrane currents in recombinant HEK 293 (human embryonic kidney) cells stably transfected with human GluR1/2 flip receptors.

IDRA 21, a positive allosteric modulator of the glutamate AMPA receptor, produced a concentration-dependent inhibition of glutamate-induced inactivation of membrane currents in recombinant HEK 293 (human embryonic kidney) cells …

2004年1月1日 · IDRA 21 is a well characterized benzothiadiazine allosteric modulator of glutamate AMPA receptors (for review, Yamada, 1998). The drug originally considered in the nootropic class of agents (which have had limited success as cognitive-enhancing agents clinically) has been shown to inhibit the rate of desensitization of the AMPA receptor during ...

IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging.

IDRA-21 shortens miniature excitatory postsynaptic currents mediated by NMDARs (NMDA-mEPSCs) in CGCs grown in low potassium with no effect on peak amplitudes. By using fast glutamate application onto CGCs nucleated patches, we found that IDRA-21 decreases both decay time constant and amplitude of the current.

One of the newest ampakines that is available on the public market is IDRA-21, which features extremely long lasting effects coupled with experimentally proven benefits. What is IDRA-21? IDRA-21 is a drug derived from the benzothiadiazine (not to be confused with benzodiazepine) chemical structure.