ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the

ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory stimulation.

2025年3月30日 · ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Cerebral Malaria. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system.

icam-1病理学意义. icam-1主要参与白细胞转运和免疫细胞募集。icam-1是lfa-1、mac-1、透明质酸、恶性疟原虫特殊蛋白等的受体，使其能够粘附于内皮细胞。这对于白细胞在免疫监视、炎症反应和免疫应答过程中渗入组织至关重要。

2024年11月1日 · ICAM-1 is a transmembrane protein characterized by its extracellular domain at the amino-terminus, a single transmembrane domain, and a cytoplasmic domain at the carboxy-terminus [4]. As a member of the immunoglobulin superfamily, ICAM-1 plays a crucial role in regulating immune responses, infection or inflammation, tissue repair processes, and ...

2023年5月19日 · Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein in the immunoglobulin superfamily expressed on the surface of multiple cell populations and upregulated by inflammatory stimuli. It mediates cellular adhesive interactions by binding to the β2 integrins macrophage antigen 1 and le …

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-end othelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ... show less

2021年12月1日 · The action of ICAM-1 is cell-type as well as stimulus-specific, tightly controlled by the concentration of cytokines, availability of particular receptor-mediated signal transduction pathways protein kinase C (PKC), the mitogen-activated protein (MAP) kinases [ERK, JNK, and p38], and the NF-κB signaling} and the transcription factors (AP1, NF ...

Know comprehensive ICAM-1/CD54 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

In their paper, Sumagin et al. have examined the role of ICAM-1 and the possible role of a leukocyte-endothelium interaction in the regulation of vascular permeability. During inflammation development, two major events occur.