Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata). [1][2][3] Basic research related to how addiction affects the brain has used this chemical. [4] Ibogamine persistently reduced the self-administration of cocaine and morphine in rats. [5] .

Ibogaine—the prototypical iboga alkaloid with the most neurobiological data—still lacks a truly robust, scalable, enantioselective total synthesis. Moreover, its biological mechanism of action is completely opaque, pushing the limits of what traditional neuropharmacology is capable of …

2025年2月6日 · Here we report a gram-scale, seven-step synthesis of ibogaine from pyridine. Key features of this strategy enabled the synthesis of three additional iboga alkaloids, as well as an enantioselective...

Ibogaine (endabuse) is a psychoactive indole alkaloid isolated from Tabernanthe iboga (Alburges and Hanson, 1999). Antiaddictive effects of ibogaine and noribogaine have been shown to be mediated via 5-HT transporter (Wei et al., 1998).

2024年7月7日 · Ibogaine has been shown to reduce opiate, amphetamine, alcohol, and nicotine self-administration in rodents. However, ibogaine itself is less than optimal as a treatment in humans for Substance Abuse Disorder (SUD) due to its cardiotoxicity and hallucinogenic potential. Instead, ibogaine is an attractive lead for drug discovery efforts.

Ibogaine is the main indole alkaloid isolated from the root bark of the African shrub Tabernanthe iboga, which has played dual roles in the lives of the population of West Africa. It was sold as an antidepressant in France for decades before its adverse …

Context: Ibogaine is the main alkaloid of the African shrub Tabernanthe iboga. It produces hallucinogenic and psychostimulant effects, but it is currently known for the anti-addictive properties.

2023年4月1日 · Ibogaine is a powerful psychoactive substance that not only alters perception, mood and affect, but also stops addictive behaviors. Ibogaine has a very long history of ethnobotanical use in low doses to combat fatigue, hunger and thirst and, in high doses as a sacrament in African ritual contexts.

2017年2月14日 · Iboga alkaloids are a particular class of indolomonoterpenes most often characterized by an isoquinuclidine nucleus. Their first occurrence was detected in the roots of Tabernanthe iboga, a sacred plant to the people of Gabon, which made it cult object.

2023年6月23日 · We describe the gram-scale total synthesis of (±)-ibogamine in nine steps and 24% overall yield. The approach features a Mitsunobu fragment coupling and macrocyclic Friedel-Crafts alkylation to establish the nitrogen-containing core of ibogamine.