Interferon-stimulated gene factor 3 (ISGF3) is the ligand-dependent transcriptional activator that, in response to interferon treatment, is assembled in the cell cytoplasm, is translocated to the nucleus, and binds the consensus DNA site, the interferon-stimulated response element.

2019年7月2日 · We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3.

2013年12月23日 · Type I IFNs activate the IFN-stimulated gene factor 3 (ISGF3) complex, which is comprised of STAT1, STAT2 and IFN-regulatory factor 9 (IRF9); the ISGF3 complex binds to IFN-stimulated...

We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3.

ISGF3, a tri-merized complex formed by STAT1, STAT2 and IRF9, recognizes the ISRE motif (TTTCNNTTTC) and induces a group of antiviral genes expression. The other complex formed by STAT1 homodimers binds to GAS motif and mainly active pro-inflammatory genes expression.

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. ISGF-3 is a multiprotein transcription factor that is very quickly activated in the cell cytoplasm only after attachment of interferon alpha to the cell surface.

2017年4月25日 · Interferon (IFN)–stimulated genes (ISGs) are antiviral effectors that are induced by IFNs through the formation of a tripartite transcription factor ISGF3, which is composed of IRF9 and phosphorylated forms of STAT1 and STAT2.

2025年3月28日 · ISGF3 then translocates to the nucleus where it binds interferon-stimulated response elements (ISRE) to activate the transcription of several interferon-stimulated genes (ISGs).

Interferon-stimulated gene factor 3 (ISGF3) is the ligand-dependent transcriptional activator that, in response to interferon treatment, is assembled in the cell cytoplasm, is translocated to the nucleus, and binds the consensus DNA site, the interferon-stimulated response element.

2023年12月18日 · To better understand the relation between ISGF3 and U-ISGF3 and STAT2/IRF9 and U-STAT2/IRF9 in IFN-I-stimulated transcriptional responses, we performed RNA-Seq and ChIP-Seq, in combination with phosphorylation inhibition and antiviral experiments.