An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1][2] Interferons bind to receptors on the surface of a cell, initiating protein …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing …

2019年3月4日 · Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and...

2018年3月1日 · 本文将简述ISGs的诱生机制，并着重叙述ISGs的各种抗病毒机制。 IFNs能够通过细胞表面受体非常快速地将信号传递至细胞内部，诱导ISGs的表达，发挥抗病毒作用。 根 …

2019年9月29日 · IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately …

2020年6月11日 · Here, we screen a library of nearly 400 interferon-stimulated genes (ISGs) against a biologically contained Ebola virus and identify several ISGs not previously known to …

Broadly speaking, an ISG is any gene whose expression is induced by IFN signaling. Advances in RNA-sequencing (RNA-seq) technology have enabled the identification of ISGs across varied …

2018年7月7日 · Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection. During virus …

干扰素刺激基因 (ISGs)是干扰素作用机制研究的核心内容.干扰素与受体结合后，通过细胞内信号转换，激活胞浆转录调控因子与ISGs调控序列上的cis元件结合而诱导基因表达. Interferon …

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous antiviral …