2023年4月28日 · Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA has been established in multiple pathogen models, but very little is known in cancer.

Irg1 缺陷型巨噬细胞以 Tet2 依赖性方式促进 T 细胞运输. 作者之前表明，CXCL9、CXCL10 和 CXCL11 这三种通过结合 T 细胞上的受体 CXCR3 吸引 T 细胞的趋化因子是 TET2 的直接靶标。 当在移植的肿瘤组织中检查 Tet 催化的 5-羟甲基胞嘧啶 (5hmC) 产生时，作者发现 Irg1-/- 肿瘤 ...

根据衣康酸衍生物或Irg1缺陷巨噬细胞的证据，已经确定了衣康酸的几个靶点，包括琥珀酸脱氢酶（SDH），它们可以阻止琥珀酸氧化为富马酸，并减少mtROS的产生。

2023年5月4日 · 线粒体代谢酶ACOD1（Aconitate decarboxylase 1；又称IRG1）在巨噬细胞激活后迅速被诱导表达，催化顺乌头酸脱羧和产生高浓度衣康酸 （Itaconate，ITA）。Irg1基因敲除小鼠的遗传研究表明，衣康酸抑制炎症基因表达和发挥抗炎作用。

2020年6月29日 · Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging as a regulator of...

ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid …

2023年4月28日 · Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA has been established in multiple pathogen models, but very little is known in cancer. Here, we show that IRG1 is expressed in tum …

2013年5月7日 · Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as the gene coding for an enzyme producing itaconic acid (also known as methylenesuccinic acid) through the decarboxylation …

2023年4月29日 · 线粒体代谢酶ACOD1 （Aconitate decarboxylase 1；又称IRG1） 在巨噬细胞激活后迅速被诱导表达，催化顺乌头酸脱羧和产生高浓度衣康酸 （Itaconate，ITA）。 Irg1基因敲除小鼠的遗传研究表明，衣康酸抑制炎症基因表达和发挥抗炎作用。 近期，IRG1/ITA在肿瘤免疫调节中的功能也被报道，但具体作用机理尚不清楚。 叶丹 课题组研究发现与肿瘤共培养的巨噬细胞中，Irg1被诱导表达并产生高水平的ITA；Irg1基因敲除改变了肿瘤微环境中TAM亚群的组成，在 …

免疫应答基因 1 (Irg1) 是一种线粒体酶，在炎症条件下产生衣康酸盐，主要在髓系细胞中。 - MCE 生物医学词典 — Master of Bioactive Molecules