We showed that the major allele of a nonsynonymous SNP rs1131665 (412Q) in IRF7 confers elevated IRF7 activation and predisposes to the development of SLE in multiple ethnic groups. …

Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). Single …

2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...

We identify the transcription factor interferon regulatory factor 7 (IRF-7), a heterodimer partner of IRF-3, as a target for non–antibiotics-based therapy of bacterial infections. We found that the …

2023年8月9日 · Accumulating evidence implies that IRF7 is a susceptibility locus for SLE. IRF7 mRNA expression is significantly increased in SLE patients, and genetic polymorphisms …

2016年9月15日 · Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterized by the production of autoantibodies against nuclear components. …

This result provides direct genetic evidence that IRF7 may be a risk gene for human SLE. These findings show that the major allele of a nonsynonymous SNP, rs1131665 (412Q) in IRF7, …

Studies on IRF7 in human SLE have expanded in the last few years due to its role in IFN expression. Indeed, genetic variants of IRF7 were shown to be associated with increased …

2012年6月1日 · Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 …

A large number of SLE-associated SNPs have been mapped to genes encoding proteins regulating or in response to type I IFNs such as genetic variants of IFN regulatory factor (IRF) …