In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line …

The activation of IRF7 through p53 signaling promoted IFN-γ production, while antiviral signals such as MX2 and EIF2AK2 were enhanced, thereby preventing immune escape from influenza …

2015年1月30日 · Meanwhile, we identify IRF7 (interferon regulatory factor 7) as a bona fide target gene of p53 to mediate the p53-directed production of type I interferon and the innate immune …

In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line …

在 DETECT 试验中，地西他滨诱导了强烈的免疫反应，其特点是 p53 突变的 TNBC 细胞系中先天免疫因子 IRF7 显着上调（上调 16 倍），并且对 TNBC 患者反应最明显。 我们的综合研究揭 …

2015年1月30日 · Meanwhile, we identify IRF7 (interferon regulatory factor 7) as a bona fide target gene of p53 to mediate the p53-directed production of type I interferon and the innate immune …

To confirm the effects of p53 on ISRE-dependent ISGs, we examined the expression of RIG-I, MxA, and IRF7 in EJp53. As shown in Fig. 2 b, p53 expression was associated with higher …

In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line …

In this report, we show that KSHV vIRF3 interacts with cellular IRF7 and that this interaction specifically suppresses IRF7 DNA binding activity and, therefore, inhibits the expression of the …

2023年12月29日 · p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast