IRF7: activation, regulation, modification and function
2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of...
Interferon‐α promotes MHC I antigen presentation of islet β cells ...
2022年3月17日 · Our study demonstrated that STAT1-IRF7-MHC I complex axis were crucial for IFN-α signalling in islets, and created positive feedback through IRF7-STAT2 cascade …
The multiple roles of interferon regulatory factor family in health …
2024年10月9日 · Interferon regulatory factors (IRFs) constitute a comprehensive category of transcription factors initially identified as regulators of type I interferon (IFN-I) and IFN …
IRF7: role and regulation in immunity and autoimmunity - PMC
The methylation of IRF7 is associated with SSc, among the methylation status of 16 CpG sites at the promoter region of the IRF7 gene, CpG2 is significantly hypomethylated in SSc PBMCs …
Role of interferon regulatory factor 7 in corneal endothelial cells ...
2021年8月13日 · The roles played by IRF7 are the viral infection-induced MHC class I upregulation and priming of the CD8 arm of acquired immunity, and not simply limited to the …
Interferon-α promotes MHC I antigen presentation of islet β cells ...
The knockdown of IRF7 decreased the IFN-α induced expressions of TAP1, PSMB8 and MHC I and prevented the expression of STAT2 but not STAT1. Our study demonstrated that STAT1 …
干扰素-α通过STAT1-IRF7通路促进1型糖尿病中胰岛β细胞的MHC I …
IRF7 的敲低降低了 IFN-α 诱导的 TAP1、PSMB8 和 MHC I 的表达，并阻止了 STAT2 而不是 STAT1 的表达。 我们的研究表明，STAT1-IRF7-MHC I 复合轴对胰岛中的 IFN-α 信号传导至关 …
Effect of interferon alpha on MHC class II gene expression in ex …
2006年6月1日 · More specifically, we propose that allele-specific differential regulation of the expression of the T1D-associated molecule HLA-DQA1 – the result of a particular …
IRF7: role and regulation in immunity and autoimmunity
2023年8月9日 · Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent …
Role of interferon regulatory factor 7 in corneal endothelial cells ...
2021年8月13日 · Interferon regulatory factor 7 (IRF7) has been identified as a significant regulator in corneal endothelial cells after an HSV-1 infection. To examine the role played by...