IRF7 通过下调促炎基因来调节 M1 到 M2 表型转换. 为了鉴定可能直接受 Irf7 调节的基因，作者接下来对 LPS 处理（2 小时）的骨髓细胞进行染色质免疫沉淀，然后进行大规模并行测序 (ChIP …

2006年9月1日 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine …

2003年10月6日 · TRAM interacts with TRIF, MyD88 adaptor-like protein (Mal)/TIRAP, and TLR4 but not with TLR3. These studies suggest that TRIF and TRAM both function in LPS-TLR4 …

In LPS-stimulated RAW264.7 cells, the depletion of LCN2 suppressed ferroptosis, inflammation, and M1 polarization. Mechanistically, IRF7 enhanced LCN2 transcription in RAW264.7 cells by …

IRF7 plays a critical role in regulating IFN-α1 expression. Exogenously expressed IRF7 increased the activation of an IFN-α1 reporter construct when TLR4/MD2- or TLR3-expressing HEK293 …

2024年12月31日 · Mechanistically, IRF7 enhanced LCN2 transcription in RAW264.7 cells by binding to its promoter region. More importantly, the silencing of IRF7 inhibited ferroptosis and …

2016年6月17日 · Viral infection or lipopolysaccharide (LPS) treatment induces expression of a large array of genes, the products of which play a critical role in host antipathogen immunity …

2024年3月26日 · We report that SRSF7 plays a role in antiviral innate immunity by controlling the transcription of IFN responsive factor 7 (Irf7), a critical player in activating the type I IFN …

LPS or viral infection induces expression of type I IFNs. Type I IFNs bind to IRNAR1 and IRNAR2 to trigger activation of ISGF3, which binds to the promoter of IRF7 and activates expression of …

TANK Is Involved in the LPS-mediated IRF3/7-activating Pathway—To demonstrate the existence of an endogenous, signal-responsive TANK-containing protein complex that phosphorylates …