IRF-7 is the master regulator of type-I interferon-dependent
2005年3月30日 · Using mice deficient in the Irf7 gene (Irf7-/-mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-α/β genes via the virus-activated, MyD88 …
Lidocaine inhibits influenza a virus replication by up-regulating …
2023年2月1日 · Upon viral infection, lidocaine activates the intracellular TBK1-IRF7 and JNK-AP1(c-Jun) axes, resulting in phosphorylation and nuclear translocation of IRF7 and …
IRF7: activation, regulation, modification and function
2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of...
IRFs: master regulators of signalling by Toll-like receptors and ...
2006年9月1日 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine …
IRF7 contribute to M1-like phenotypes through the activation of ...
Yang et al. revealed that the acquisition of M1 characteristics in leukemiaassociated macrophages (LAMs) through activation of the IRF7-SAPK/JNK pathway was associated with prolonged …
Transcriptional repression of IRF7 by MYC is critical for type I ...
We demonstrate that transcriptional repression of IRF7 by MYC provides an additional layer of tight regulation of IRF7 that ensures the appropriate level of type I IFN production and …
Lidocaine inhibits influenza a virus replication by up ... - PubMed
Mechanistically, lidocaine upregulated IFNα4 by activating TANK-binding kinase 1 (TBK1)-IRF7 and JNK-AP1 signaling pathways. These findings indicate that lidocaine has an incredible …
Full article: Repolarizing heterogeneous leukemia-associated ...
2017年12月26日 · Targeting IRF7-SAPK/JNK pathway, which accounted for different activation of LAMs, to induce M1 characteristics contributed to prolonged survival in leukemia mice. Our …
IRF7 activation by Epstein–Barr virus latent membrane protein 1 ...
2008年11月11日 · Epstein–Barr virus (EBV) latent infection membrane protein 1 (LMP1), a constitutively aggregated and activated pseudoreceptor, activates IFN regulatory factor 7 …
IRF3 and IRF7 Phosphorylation in Virus-infected Cells
2001年3月23日 · While production of viral products such as dsRNA play a role in activation of IKK and possibly of JNK (12), the data reported here suggest that additional signals stimulate …