IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell …

Mar 30, 2025 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus …

Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in …

IRF5 是一种关键的转录因子，通过协调 I 型干扰素 (IFN) 基因（包括 IFNA 和 INFB）以及内溶酶体 Toll 样受体（TLR7、TLR8 和 TLR9）下游炎症细胞因子的激活，在先天免疫中发挥关键作 …

Nov 28, 2024 · IRF5已被证明是各种SLE小鼠模型中疾病发展所必需的，可作为SLE的治疗靶点。 IRF5在SLE患者中异常表达和激活，并通过诱导I型干扰素、促炎细胞因子的表达，调节自身 …

Jan 1, 2024 · This review serves to summarize the literature regarding the role of IRF5 in malignant transformation, cancer progression, association with prognosis and outcome, as …

Oct 9, 2024 · Interferon regulatory factors (IRFs) constitute a comprehensive category of transcription factors initially identified as regulators of type I interferon (IFN-I) and...

Sep 10, 2018 · IRF5 is a key factor in defining the inflammatory macrophage phenotype. IRF5 is highly expressed in not only monocytes and macrophages but also in B cells and dendritic …

干扰素调节因子 5： 该基因编码干扰素调节因子 (IRF) 家族的一个成员，该家族是一组具有不同作用的转录因子，包括病毒介导的干扰素激活以及细胞生长、分化、凋亡和免疫系统活性的调节 …

Aug 2, 2016 · IRF5 was first identified and characterized as a transcriptional regulator of type I interferon expression after virus infection. In addition to its critical role (s) in the regulation and...