IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity.

2025年3月30日 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus Erythematosus 10 . Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-like receptor signaling pathway .

Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in different laboratories over the last decade have placed IRF5 as ...

The IRF5 protein is a key transcription factor in innate immunity and activates type I interferon (IFN) and inflammatory cytokine genes through endolysosomal Toll-like receptors (TLR7, TLR8, TLR9). It regulates IFN genes and IFN-stimulated genes …

2024年1月1日 · IRF5 can be hypomethylated resulting in overexpression or induced through viral-mediated Tax activation of the pV3 IRF5 promoter. IRF5 then activates AP-1 and downstream release of excess pro-inflammatory cytokines leading to immune escape, angiogenesis, and uncontrolled tumor growth.

2024年11月28日 · irf5是参与sle发病的关键转录因子，其异常表达和激活与遗传变异有关。 本研究确定位于远端的rs4728142作为增强子元件，其遗传变异可调控IRF5的表达。 02： rs4728142等位基因对IRF5表达的影响

一般来说，转录因子干扰素调节因子 5 (IRF5) 是 Toll 样受体 (TLR) 等病原体识别受体下游先天性和适应性免疫的关键介质。 因此，IRF5功能失调广泛涉及炎症和自身免疫性疾病。

干扰素调节因子 5： 该基因编码干扰素调节因子 (IRF) 家族的一个成员，该家族是一组具有不同作用的转录因子，包括病毒介导的干扰素激活以及细胞生长、分化、凋亡和免疫系统活性的调节。 IRF 家族成员的特征是包含色氨酸 (W) 重复序列的保守 N 端 DNA 结合域。替代启动子的使用和替代剪接会导致 ...

This review will provide an in-depth overview of the current literature regarding the mechanisms by which IRF5 functions as either a tumor suppressor or oncogene, its role in metastasis, regulation of the tumor-immune microenvironment, utility as a prognostic indicator of disease, and new developments in IRF5 therapeutics that may be used to ...

The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Learn about this gene and related health conditions.