Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. [5][6][7] IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8][9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myel...

2025年3月30日 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Immunodeficiency 131. Among its related pathways are MITF-M-dependent gene expression and Signaling by ALK in …

Interferon Regulatory Factor 4 (IRF4) Promotes Lipopolysaccharide-Induced Colonic Mucosal Epithelial Cell Proliferation by Regulating Macrophage Polarization. A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.

We first outline the complex role of IRF4 in the function of CD4 + T cells and then discuss recent studies from our laboratory that have revealed a surprising role for components of Rho guanosine triphosphatase-mediated pathways in controlling the activity of IRF4.

2024年11月5日 · Interferon regulatory factor 4 (IRF4) is an oncogenic transcription factor (TF) in several hematological malignancies. In multiple myeloma (MM), IRF4 serves as an MM-specific regulator of cell survival, making it an ideal target for therapy development.

What is the IRF4 gene? The interferon regulatory factor 4 ( IRF4 ) gene belongs to a family of DNA -binding proteins that play an important role in immune system development and function [1]. IRF4 polymorphisms have been independently associated with pigmentation and age-specific effects on melanocytic naevus count in European-derived ...

Interferon regulatory factor 4 (IRF4) is a unique IRF family member that is not regulated by interferons, instead, is mainly induced upon T-cell receptor signaling, Toll-like receptors and tumor necrosis factor receptors.

2016年11月9日 · IRF4 is a hematopoietic-specific transcription factor critical for lymphoid and myeloid lineage development and function, and its expression is thus restricted to immune cells such as T cells, B cells, macrophages, and dendritic cells (DCs). Herein, we summarize the specific roles of IRF4 in immune cell development.

2025年2月19日 · Title: Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis. IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.

Genetic variants in IRF4 define the skin/hair/eye pigmentation variation locus 8 (SHEP8) [MIM:611724]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to …