IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2 . IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain , a C-terminal IRF association domain and several ...

2006年9月1日 · Both IRF3 and IRF7 are activated by TBK1 (TANK (tumour-necrosis-factor-receptor-associated factor (TRAF)-family-member-associated nuclear factor (NF-κB) activator)-binding kinase 1), which...

2021年11月2日 · Our results demonstrate that IFN-I-inducible lncRNA-ISIR feedback strengthens IRF3 activation by removing suppressive Fli-1 in immune responses, revealing a method of lncRNA-mediated modulation of transcription factor (TF) activation.

2015年4月17日 · IRF3 gene promoter shows a moderate response to NF-κB in 4 out of 10 cases, located in the region (0b, 500b) upstream of TSS. Strong peak for IRF1 is located in the same region as the signal for NF-κB binding, overlapping the region of weak signal for IRF3.

在这项研究中，我们确定了与 CREB 结合蛋白 (CBP) 结合的磷酸化人和小鼠 IRF-3 的晶体结构，这表明磷酸化的 IRF-3 通过 pSer386（小鼠 IRF-3 中的 pSer379）和下游 pLxIS 基序形成二聚体。 尺寸排阻色谱和基于细胞的研究表明，与 pSer386 相互作用的关键残基的突变会严重损害 IRF-3 激活和 IFN-β 诱导。 相比之下，人 IRF-3 的 pLxIS 基序中 Ser396 的磷酸化仅在 IRF-3 激活中起中等作用。 小鼠IRF-3/CBP复合结构揭示小鼠IRF-3激活机制与人IRF-3相似但不同。 这些结构 …

The autophagic degradation of IRF3 mediated by PSMD14 or CALCOCO2 ensures the precise control of IRF3 activity and fine-tunes the immune response against viral infection. Our study reveals the regulatory role of PSMD14 in balancing IRF3-centered IFN activation with immune suppression and provides insights into the crosstalk between selective ...

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the human innate antiviral immune responses with production of interferons (IFNs) as a hallmark outcome of activation. In recent years, IRF3 has been considered a principal early regulator of type I IFNs (TI- …

2021年11月2日 · Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, …

IRF3 (Interferon regulatory factor 3) 作为干扰素调节因子的一员，在抗病毒天然免疫防御方面发挥重要作用。 IRF3 可以调节IFN和IFN诱导基因（ISG）的表达。 干扰素调节因子家族包括 9 个成员。

2010年12月6日 · During reverse transcription (RT)-PCR to clone the full-length open reading frame (ORF) of IRF3, we cloned a full-length ORF encoding an isoform of IRF3, termed as IRF3-CL, and has a unique carboxyl-terminus of 125 amino acids. IRF3-CL is ubiquitously expressed in distinct cell lines.