Crystal structure of IRF-3 in complex with CBP - PubMed
The crystal structure of IRF-3 in complex with CBP reveals that CBP interacts with a hydrophobic surface on IRF-3, which in latent IRF-3 is covered by its autoinhibitory elements. This …
S‐glutathionylation of IRF3 regulates IRF3–CBP interaction and ...
2008年2月28日 · We show that deglutathionylation of IRF3 is necessary for efficient interaction of IRF3 with CBP, an event essential for transcriptional activation of the interferon genes. Taken …
The Structural Basis of IRF-3 Activation Upon Phosphorylation
Here, we determined the crystal structures of phosphorylated human and mouse IRF-3 bound to CBP (cAMP response element binding protein (CREB)-binding protein), which reveal that …
Transcription factor dimerization activates the p300 ... - Nature
2018年10月15日 · Activated IRF3 dimers bind to p300/CBP (where CBP is CREB-binding protein; p300 and CBP are also known as KAT3B and KAT3A, respectively) to stimulate chromatin …
磷酸化后 IRF-3 激活的结构基础,The Journal of Immunology - X-MOL
In this study, we determined the crystal structures of phosphorylated human and mouse IRF-3 bound to CREB-binding protein (CBP), which reveal that phosphorylated IRF-3 forms a dimer …
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and ...
2008年3月19日 · We show that deglutathionylation of IRF3 is necessary for efficient interaction of IRF3 with CBP, an event essential for transcriptional activation of the interferon genes. Taken …
1ZOQ: IRF3-CBP complex - RCSB PDB
2005年5月13日 · Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 …
Crystal Structure of IRF-3 in Complex with CBP - Cell Press
The crystal structure of IRF-3 in complex with CBP reveals that CBP interacts with a hydrophobic surface on IRF-3, which in latent IRF-3 is covered by its autoinhibitory elements. This …
Interferon regulatory factor 3 and CREB-binding protein/p300 are ...
Two of the components of DRAF1 have now been identified as interferon regulatory factor 3 (IRF-3) and the transcriptional coactivator CREB-binding protein (CBP)/p300. We demonstrate that …
Frontiers | Therapeutic Targeting of IRFs: Pathway-Dependence or ...
2018年11月19日 · The IRF3 crystal structure in its latent (unstimulated or autoinhibited monomer) form revealed the hydrophobic surface and a region essential for CBP/p300 binding that is …