Interferon regulatory factor 3 is a key regulation factor for inducing ...
2016年7月14日 · We show that the TLR3 and RIG-I/MDA5 pathways participate in the regulation of SAMHD1 expression and find that IRF3 phosphorylation and nuclear translocation are critical aspects of SAMHD1...
文献分享 | Immunity：嘧啶合成酶CTP合成酶1通过对IRF3进行脱酰 …
wt irf3、irf3-n85d和irf3-n85a激活免疫基因表达的能力也与sev感染应答时ifn-β和cxcl10的产生相关（图 5d）。这些结果表明脱酰胺抑制了irf3介导的ifns和isgs的表达。
Adenovirus construction and effects of IRF-3 5D and IRF
Macrophages transduced with activated IRF3 had increased expression of IL-12, decreased expression of VEGF and MMP-2, and enhanced tumoricidal functions against multiple human cancer cell lines...
Selective autophagy controls the stability of transcription factor IRF3 …
2020年5月31日 · Our study reveals the regulatory role of PSMD14 in balancing IRF3-centered IFN activation with immune suppression and provides insights into the crosstalk between selective autophagy and type I IFN signaling.
干扰素调节因子3促结直肠癌细胞增殖与侵袭相关探索
构建野生型irf3（irf3-wt）和irf3-5d过表达的结直肠癌细胞ct26、colon26，采用细胞计数法、细胞划痕试验和克隆形成试验检测细胞增殖及迁移能力。 结果·TCGA数据分析提示癌组织中IRF3蛋白表达水平与患者的不良预后呈正相关。
Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to …
2023年1月19日 · UAP1-mediated IRF3 pyrophosphorylation at Ser 386 was a required step for its subsequent phosphorylation of Ser 396 as well as the dimerization of IRF3. Taken together, our findings uncovered UAP1 as an important pyrophosphorylase for IRF3 pyrophosphorylation to promote the activation of type I IFN signaling and innate antiviral responses.
The TAK1-JNK cascade is required for IRF3 function in the
2009年1月20日 · Interferon regulatory factor (IRF)3 is critical for the transcriptional induction of chemokines and cytokines during viral or bacterial invasion. The kinases Tank binding kinase (TBK)1 and...
Inhibition of cGAS-STING-TBK1 signaling pathway by
2018年11月30日 · The DP96R gene of ASFV encodes one of the viral virulence factors, yet its action mechanism remains unknown. In this study, we report that DP96R of ASFV China 2018/1 strain subverts type I IFN production in cGAS sensing pathway. DP96R inhibited the cGAS/STING, and TBK1 but not IRF3-5D mediated IFN-β and ISRE promoters activation.
Activation and evasion of type I interferon responses by SARS-CoV-2
2020年7月30日 · We found that overexpression of ORF6-M1 inhibited IFN-β promoter activation triggered by RIG-IN, MDA5, MAVS, and IRF3-5D to a comparable or lower level to that observed in the overexpression of...
GSK3 inhibits IRF3 transactivation activity. (A) IRF3 expression...
Upon virus infection, the host innate immune response is initiated through the activation of IFN regulatory factor 3 (IRF3) and NF-κB signaling pathways to induce IFN production. Previously, we...