Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. [4][5] Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified.

2024年12月25日 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related pathways are Bacterial infections in CF airways and Overview of …

2021年1月21日 · Given the diverse array of effectors that exist in the IRF1 regulome, understanding the mechanisms underlying the protective role of IRF1 can be expected to provide key insights into microbial infections and host defense, as well as cancer biology where IRF1 also plays a pivotal role in disease outcome.

Innate immune signaling can induce the expression of interferon (IFN) regulatory factor 1 (IRF1), an important molecule in innate immune activation and cell death. While IRF1 has been shown to modulate some RCD pathways, a comprehensive evaluation of its role specifically in inflammatory cell death pathways is lacking.

irf1是最早发现的具备调节 干扰素 转录表达调控功能的高效调节因子。多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。 多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。

编码的蛋白质激活参与机体对病毒和细菌反应的基因的转录，在细胞增殖、细胞凋亡、免疫反应和 DNA 损伤反应中发挥作用。 这种蛋白质抑制其他几个基因的转录。 作为肿瘤抑制因子，它既能抑制肿瘤细胞生长，又能刺激针对肿瘤细胞的免疫反应。 该基因的缺陷与胃癌、骨髓性白血病和肺癌有关。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and …

2021年1月21日 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader …

IRF1 re-expression in human cancer cells causes cells to become resistant to infection by the oncolytic vesicular stomatitis virus strain. IRF1 is a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion.

IRF1 编码干扰素调节因子1蛋白（IRF1），作者在HEK293T细胞中 瞬时转染 p.R129*和p.Q35*，发现这两个突变体丧失了转录活性，无法产生IRF1。 RT-qPCR显示P1和P2中mRNA的水平都比对照组要低，P1中p.R129*使得 IRF1 转录本发生NMD，从而缺乏可检测的蛋白，P2中p.Q35*尽管可通过翻译再起始逃脱一部分的NMD，但产生蛋白水平极低，两位患者中都存在IRF1缺陷。 那么IRF1在白细胞发育中起什么样的作用呢？

2006年9月1日 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4,14. IRF1 was the first IRF-family member that was discovered to ...