3 天之前 · IRF-1 (D5E4) XP ® Rabbit mAb recognizes endogenous levels of total IRF-1 protein. Human, Mouse, Rat. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro261 of human IRF-1 protein.

2021年1月21日 · In 1988, IFN-regulatory factor 1 (IRF1), the first member of the IRF family to be recognized, was identified by the Taniguchi laboratory in crude nuclear extracts of Newcastle disease virus (NDV)-infected mouse L929 cells using DNA affinity column chromatography [3].

IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, [7] which is highly conserved among all IRF proteins.

2011年9月1日 · Interferon regulatory factor (IRF)-1 is an immunomodulatory transcription factor that functions downstream of pathogen recognition receptor signaling and has been implicated as a regulator of type I interferon (IFN)-αβ expression and the immune response to virus infections.

2023年10月27日 · We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis.

2021年3月23日 · We found that TLR4 activation in MDMs enables chromatin opening at ISG loci. Finally, we identified an essential role for IRF1 in regulating chromatin accessibility and expression of ISGs in human macrophages. These results reveal lineage-specific and stimuli-specific heterogeneity within human innate immune responses.

2014年12月11日 · Here, we identify interferon regulatory factor 1 (IRF1) as a novel critical regulator of Smac mimetic BV6-induced apoptosis and proinflammatory cytokine secretion with impact on the immune...

2023年2月2日 · IRF1 encodes interferon regulatory factor 1 protein (IRF1), a transcription factor induced by IFN-γ, the deficiency of which in mice underlies susceptibility to various pathogens, including mycobacteria 43,44,45,46,47,48,49,50,51,52,53,54,55,56,57 (Table S2).

2025年3月1日 · Interferon regulatory factor 1 (IRF1) ... activity of IRF1 (Fig. 5B), leading us to conclude that the E1 element was indeed the main active unit within IRF-SE. To further validate this finding, CRISPR-Cas9 was employed to knock out the E1 region. ... Kalfon J, Perez MW, et al. Leukemia core transcriptional circuitry is a sparsely interconnected ...

2025年1月7日 · Together, our results reveal how combinatorial logic gates of IRF1-ISGF3 or IRF1-GAF restrict immune epigenomic memory formation to macrophages exposed to pathogens or IFN-γ-secreting T cells but not bystander macrophages exposed transiently to type I IFN.