2025年2月8日 · This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most …

2022年12月14日 · IRAK4 Degrader (KT-474) Part C of Kymera’s KT-474 Phase 1 clinical trial was designed to confirm that the PK/PD and safety data previously demonstrated in healthy …

2019年6月13日 · Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses.

2024年12月25日 · IRAK4 (Interleukin 1 Receptor Associated Kinase 4) is a Protein Coding gene. Diseases associated with IRAK4 include Immunodeficiency 67 and Immunodeficiency 33. …

2024年12月1日 · Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal …

Mutually exclusive expression of a hypermorphic long IRAK4 (IRAK4-L) isoform over a hypomorphic short (IRAK4-S) isoform predicts clinical aggressiveness and worse outcomes in …

2025年2月17日 · The IL-1R/TLRs signaling pathway holds a pivotal position within the innate immune system, highlighting its importance in various pathological processes. IRAK4, as the …

2023年10月5日 · IRAK-4 is a key signal transduction node in the regulation of IL-1R and TLRs pathways. Targeting IRAK-4 is a promising method for inflammation, auto-immune diseases …

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) is a key mediator of innate immunity. IRAK4 overactivation is linked with several autoimmune diseases. To date, many IRAK4 inhibitors …

2025年1月6日 · Interleukin-1 receptor-associated kinase 4 (IRAK4) is involved in various inflammation-related diseases. Both the kinase and scaffolding functions of IRAK4 initiate pro …