The IL23R mRNA is 2.8 kilobases in length and includes 12 exons. The translated protein contains 629 amino acids; it is a type I penetrating protein and includes a signal peptide, an N-terminal fibronectin III-like domain and an intracellular part that contains three potential tyrosine phosphorylation domains. [6] .

2024年12月25日 · IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17 and Psoriasis 7. Among its related pathways are Akt Signaling and Cytokine production by Th17 cells in CF (Mouse model).

2024年12月10日 · In plasma from humans across the lifespan, IL-23R increased with age. Our results reveal circulating factors as candidate mediators of senescence-associated interorgan signal transduction and...

2023年10月14日 · Here, we focus on two questions: what are the immune cells that express the IL23R and how is IL23R expression acquired. The IL-23R: Structure and signaling IL-23 is a heterodimeric cytokine formed by two disulfide-bound subunits: p19 (encoded by IL23A ) and p40 (encoded by IL12B ) [ 1 ].

这种蛋白质与受体分子 IL12RB1/IL12Rbeta1 配对，两者都是 IL23A 信号传导所必需的。 该蛋白与 Janus 激酶 2 (JAK2) 组成性结合，并且还以配体依赖性方式与转录激活因子 STAT3 结合。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling.

2023年5月19日 · In this study, we use a fluorescent version of IL-23 to characterise antagonists of the full-length receptor expressed by living cells using a NanoBRET competition assay. We then develop a cyclic...

梅奥医学中心 的研究人员在 Nature Aging 期刊发表了题为： IL-23R is a senescence-linked circulating and tissue biomarker of aging 的研究论文。 该研究表明， 白细胞介素-23受体 （IL-23R）是一种衰老相关的循环和组织生物标志物。 细胞衰老 是一种年龄相关机制，参与多种器官系统的发病，包括 免疫 功能障碍 、心 血管 和代谢性疾病、肺纤维化、 骨质疏松 、 肾脏疾病 、肝损伤、 肌肉减少症 和认知功能下降等。 衰老血液中的因子可驱动许多组织的衰老和炎症激活 …

2015年10月1日 · Interleukin (IL-)23 is a central cytokine controlling T H 17 development. Overshooting IL-23 signaling contribute to autoimmune diseases. IL-23 is a member of the IL-12-type cytokine family and consists of IL-23p19 and p40. IL-23 triggers heterodimerization of IL-12Rβ1 and the IL-23R.

The IL23R gene provides instructions for making a protein called the interleukin 23 (IL-23) receptor. This protein is embedded in the outer membrane of several types of immune system cells, including T cells, natural killer (NK) cells, monocytes, and dendritic cells.

Macrophage-mediated inflammatory pathways are key contributors to IBD pathogenesis, and we identify an autocrine/paracrine IL23 requirement in PRR-initiated human macrophage outcomes and in human intestinal myeloid cells, establish that IL23R undergoes ligand-induced recycling, define mechanisms reg …