Sep 1, 2020 · The interleukin (IL)-2 receptor (IL-2R) α-chain (CD25) is being shed upon immune activation. Increased levels of soluble (s)IL-2R, therefore, are considered as an indication of an on-going immune response which could be used to monitor immune-mediated diseases.

Aug 8, 2018 · IL-2 interacts with three classes of IL-2 receptor with different affinities for IL-2; IL-2 binds with low affinity (K d ~10 −8 M) to receptors containing only IL-2Rα, with intermediate ...

Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction. The IL-2Rβ chain couples to JAK1, and the γ chain (γ c ) couples to JAK3.

IL-2 receptor (IL-2R) is considered as a heterotrimeric protein that represents three subunits or chains: α (CD25), β (CD122) and γ (CD132). The different and separate expressions of these receptor chains on various immune cell types is associated with diverse functionality of IL-2 …

Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance.

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo.

Mar 12, 2024 · Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells.

A soluble form of the interleukin-2 receptor (sIL-2R) is secreted upon T-cell activation. Increased blood levels of sIL-2R occur in a variety of immunological diseases.

Feb 17, 2012 · Under steady-state resting conditions, interleukin-2 (IL-2) is mainly produced by activated CD4 + T cells in secondary lymphoid organs. The secreted IL-2 is then consumed at the same site by...

The receptor for IL-2 consists of at least three distinct subunits, the alpha chain (IL-2R alpha), the beta chain (IL-2R beta), and the gamma chain (IL-2R gamma). Although the role of IL-2R gamma in IL-2 signalling remains unclear, IL-2R beta is the …