IL-2 regulates tumor-reactive CD8 - Nature
2021年1月11日 · This study reveals a double-edged role for IL-2 in regulating tumor-specific CD8 + T cells. IL-2 can promote CD8 + T cell activation and proliferation at an early tumor stage, …
IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell
2024年7月1日 · We explored the theory that targeting of IL2 to CD8+ T cells, which are key antitumor effectors, could enhance its therapeutic index. To this aim, we developed AB248, a …
Intrinsic IL-2 production by effector CD8 T cells affects IL-2
2022年2月11日 · IL-2 is known to play multiple roles during the generation of effector and memory CD8 T cell responses. Here, Kahan et al. show that a subset of CD8 T cells with the capacity …
IL-2 regulates tumor-reactive CD8 - PubMed
We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8 + T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing …
Nature子刊：颠覆性发现，T细胞生长因子IL-2还能促进T细胞耗竭|Nature|CD8…
2021年1月14日 · 2021 年 1 月 11 日，中国医学科学院北京协和医学院黄波教授团队在 Nature Immunology 杂志在线发表了题为：IL-2 regulates tumor-reactive CD8+ T cell exhaustion by …
IL-2 delivery to CD8 - Nature
2024年9月11日 · Here authors show that MRTF/SRF inactivation leads to decreased IL-2 mediated CD8 + T cell proliferation during infection, resulting from disrupted homotypic cell …
An engineered IL-2 partial agonist promotes CD8 - Nature
2021年9月15日 · Here we show that H9T, an engineered interleukin-2 partial agonist, promotes the expansion of CD8 + T cells without driving terminal differentiation. H9T led to altered …
Interleukin-2 signaling in the regulation of T cell biology in ...
2024年3月12日 · The balance between short-lived Teff and memory precursors is regulated by duration of antigen exposure and inflammatory cytokines as well as the concentration and …
IL-2-driven CD8+ T cell phenotypes: implications for …
2023年10月10日 · Strong IL-2 receptor stimulation of antigen-activated CD8 + T cells induces a unique gene expression program in which the cells harbor a superior cytotoxicity and …
新型受体偏向性IL-2组合改善免疫细胞命运及肿瘤免疫治疗效果
3 天之前 · 近日，我室院周德敏、纪德重团队在 Advanced Science 发表最新成果，他们通过设计具有协同效应的受体偏向性 IL-2 变体组合，实现了对调节性 T 细胞（ Treg ）和 CD8+ T 细胞 …