Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity …

Apr 16, 2019 · Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, …

Mar 22, 2024 · IL-17 inhibitors block the inflammatory pathway of interleukin-17A. These biologic medications are an extremely effective FDA-approved treatment option for people with …

Oct 11, 2023 · IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and …

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25th …

Interleukin (IL)-17A, the founding and most studied member of the IL-17 family, was cloned in 1993 and initially named cytotoxic T lymphocyte-associated antigen 8 (CTLA-8).

Mar 30, 2025 · IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several …

Jul 5, 2022 · IL-17A and IL-17F are produced by CD4 + and CD8 + T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective …

Jul 24, 2023 · The pleiotropic ability of cytokines such as IL-17A and IL-17F to regulate inflammatory processes and tissue repair is being unveiled at a fast pace and is of immense …

Jan 1, 2020 · IL-17A is the hallmark of the Th17 subset of CD4 lymphocytes, which also produce IL-17F, IL-22 and IL-21. Th17 differentiation is dependent on the presence of proinflammatory …