2021年2月21日 · The central contribution of IL-23/IL-17 axis in both PsA and psoriasis is confirmed by the efficacy of biologics neutralizing IL-17 or IL-23/IL-12 (187) as well as the effectiveness of TNF-α inhibition dependent on down-regulation of IL …

2024年9月8日 · The pivotal role of interleukin-23 (IL-23) in the pathogenesis of PsA has become increasingly evident. This proinflammatory cytokine is markedly elevated in patients with PsA, suggesting its potential as a therapeutic target. Consequently, IL-23 inhibitors have emerged as promising first-line biologic treatments for PsA.

2019年8月1日 · Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, which significantly contributes to the maintenance and reestablishment of immune homeostasis. However, this classical view fails to fully describe the pleiotropic roles of IL-10.

2020年9月1日 · IL-2 is involved in immunity, but is also important for maintenance of tolerance. The functional role of soluble IL-2R is controversial varying from activation to suppression of immunity. Measuring sIL-2R in clinical practice may be relevant for diagnosis, prognosis and/or monitoring immune-mediated diseases.

The interleukin (IL-)2 – IL-2 receptor (IL-2R) pathway plays a paradoxical, but pivotal, role in the outcome of both immunity as well as tolerance and this is effectuated via multiple types of immune cells (e.g., monocytes, macrophages, T-, B-, natural killer (NK)- and dendritic cells (DCs)) [2, 3].

2022年3月8日 · Resolution of chemotherapy-induced peripheral neuropathy (CIPN) after treatment completion depends on CD8+ T cells and on IL-10 produced by other cells. Using Rag2-/- mice lacking T and B cells and adoptive transfer of Il13-/- CD8+ T cells, we showed that CD8+ T cells producing IL-13 were required for resolution of CIPN.

2024年12月6日，复旦大学生命科学学院于肖飞团队在Immunity发表了题目为Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like...

2010年2月23日 · The role of IL-1 in disease is exemplified by the description of hereditary autoinflammatory diseases caused by excessive IL-1 signaling secondary to either IL-1β overproduction or IL-1Ra...

2019年8月15日 · Interleukin-10 (IL-10) is crucial for controlling these T-cell responses, but the precise mechanism of inhibition remains unclear. A better understanding of how IL-10 exerts...

In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated in liver regeneration, but also in metabolic function of the liver.