IL-4 Signaling Pathways - R&D Systems
IL-4 initiates signal transduction through one of two different receptor complexes, a type I receptor expressed on hematopoietic cells or a type II receptor expressed on nonhematopoietic cells.
Recent advances in understanding the role of IL-4 signaling
2021年9月7日 · In this review, we cover critical older information but also highlight newer advances. An area of evolving interest relates to the therapeutic blockade of IL-4 signaling pathway to treat atopic dermatitis and asthma.
Interleukin-4 receptor signaling and its binding mechanism: A ...
2016年12月1日 · Interleukin-4 is the prime anti-inflammatory cytokine involved in cell proliferation, gene expression and apoptosis. α chain of IL-4R is also a fundamental part of IL-13R hence, signifying its role in both IL-4 and IL-13 signaling pathway.
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL …
2018年6月6日 · In T-cells, IL-4 induces the differentiation of naïve CD4 T cells into Th2 cells, in B cells, IL-4 drives the immunoglobulin (Ig) class switch to IgG1 and IgE, and in macrophages, IL-4 and IL-13 induce alternative macrophage activation. This review gives a short insight into the functional formation of these cytokine receptors.
Recent Advances in the Inhibition of the IL-4 Cytokine Pathway …
The IL-4 signaling pathway involves numerous transmembrane peptides and intracellular signaling molecules, which produce unique responses dependent on cell type. The transmembrane receptor for IL-4 is IL-4Rα.
COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING
IL-4 and IL-13 take advantage of numerous signaling molecules to trigger activation and gene transcription namely 2 main pathways; the STAT6 pathway and the IRS pathway. STAT6 signaling in asthma is well characterized.
Evolution and function of interleukin-4 receptor signaling in …
2020年3月6日 · The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins.
The IL-4 receptor: signaling mechanisms and biologic functions
Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various mechanisms through which receptor function is modulated.
IL-4 in the Brain: A Cytokine To Remember
2012年11月1日 · IL-4 signaling pathways. After IL-4 binding IL-4Rα, the IL-4R is created by dimerization with the common γ-chain (γc) to create the type 1 signaling complex or with IL-13Rα1 to create the type 2 complex.
Regulation of inflammation by interleukin-4: a review of …
In this review, recent advances in understanding these three IL-4-related branch points—alternative splicing of IL-4, differential receptor engagement by IL-4, and differential regulation of macrophage activation by IL-4—are summarized in light of …
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