Mar 30, 2025 · Complete information for IKBKG gene (Protein Coding), Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma, including: function, proteins, disorders, pathways, orthologs, and expression.

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. [5] . The human gene for IKBKG is located on the chromosome band Xq28. [6] .

The IKBKG gene provides instructions for producing one piece (subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Nuclear factor-kappa-B is a protein complex that binds to …

Jan 12, 2025 · Dysfunctional inhibitor of nuclear factor-κB (NF-κB) kinase regulatory subunit gamma (IKBKG) is known to trigger incontinentia pigmenti (IP), anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID), immunodeficiency (ID), and IKBKG deleted exon 5 autoinflammatory syndrome (NDAS).

该基因编码 kappaB 激酶 (IKK) 复合物抑制剂的调节亚基，激活 NF-kappaB，从而激活参与炎症、免疫、细胞存活和其他途径的基因。 该基因的突变会导致色素失禁、少汗性外胚层发育不良和其他几种类型的免疫缺陷。 与该基因座高度相似的假基因位于 X 染色体的相邻区域。 [RefSeq 提 …

IKBKG - inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, …

IKBKG 基因，又称核因子κb关键因子 (nuclear factor κB essential modulator, NEMO)，其编码蛋白参与IκB激酶 (inhibitor of kappa B kinase，IKK)复合物的形成，在接受各种上游信号刺激后，介导IκBα的降解，并最终导致核因子κB (nuclear factor-κB, NF-κB)通路的激活，是NF-κB信号通路的关键调节分子，在固有免疫及适应性免疫中发挥重要作用，并参与调节血管生成、骨代谢等多种生物学过程 [1]。 IKBKG 基因在体内广泛表达，遍布外胚层、中胚层及外胚层来源细胞。

IKBKG, or NEMO, is the founding member of an evolutionarily conserved family of NEMO-like kinases that function in numerous cell signaling pathways. NEMO-like kinases specifically phosphorylate serine or threonine residues that are followed by a proline residue ( …

Apr 5, 2012 · This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways.

ikbkg的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为这个基因编码κb的激酶（ikk）复合体抑制剂，激活的nf-κb的导致参与炎症，免疫，细胞存活，和其它途径的基因的活化的调节亚基。