MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly …
In our cohort of 127 central-review confirmed pedHGG patients with evaluable MMR-IHC, staining of MSH2, MSH6, MLH1, and PMS2 successfully identified all present cases with LS and …
Heterogenous loss of mismatch repair (MMR) protein expression: a ...
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour …
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly …
2025年2月2日 · Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch …
错配修复系统（MMR）蛋白与微卫星不稳定性（MSI）检测结果小 …
免疫组化 (IHC) 方法价廉、耗时少，病理科可以常规用于检测 MMR 蛋白，可用于小肿瘤标本检测。 所以近年来大多采用 IHC 对 MMR 蛋白进行检测，并有国内外的研究显示预测 MSI状态其 …
病理报告看不懂？一文详解临床常见免疫组化指标 - 知乎
肠癌患者的IHC： 微卫星不稳定（MSI）： 表达于大约 90% Lynch综合征和 10%~15%散发性结直肠癌。 MSI由错配修复基因 （mismatch repair, MMR）缺陷造成。 主要是 MLH1、MSH2 …
胃癌常用免疫组化指标解读，看这一篇就够了！|表达|肿瘤|胃癌|蛋 …
2022年5月31日 · 2021 CSCO指南推荐胃腺癌患者均需行IHC检测HER2表达状态（IA类），必要时行原位杂交（ISH）/荧光原位杂交（FISH）检测。 IHC评估肿瘤细胞的膜状免疫染色，包 …
Relationship between MLH1, PMS2, MSH2 and MSH6 gene …
In the current study, we demonstrate MMR gene and protein expression associated variation in TMB; our data show that tumors with loss of MLH1/PMS2 co-expression by IHC are …
Immunohistochemistry (IHC)
Immunohistochemistry (IHC) testing can be performed on tumor tissue to analyze mismatch repair protein function. The pattern of loss observed can provide information about which gene is not …
Detection of MMRd can be carried out through immunohistochemistry (IHC) for the MMR proteins or through MSI testing. The two methods have comparable sensitivity and show approximately …
Epidemiology, pathogenesis, biology and evolving management …
5 天之前 · IHC staining for MSH2, MSH6, MLH1 and PMS2 is also recommended to limit false-negative results as compared with staining for MSH6 and PMS2 only 103.