Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity.

2020年11月25日 · igfbp-3是出生后血液中含量最丰富的一种igf结合蛋白。 它与IGF结合，防止它们被降解，促进IGF在身体各部分的运输，对IGFs结构进行修饰从而改变IGFs与其特异性受体之间的相互作用。

igfbp-3是出生后血液中含量最丰富的一种igf结合蛋白。 它与IGF结合，防止它们被降解，促进IGF在身体各部分的运输，对IGFs结构进行修饰从而改变IGFs与其特异性受体之间的相互作用。

2020年5月5日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent as well as in an IGF-independent manner. The IGF-dependent roles of IGFBP-3 include its endocrine role in the delive …

Insulin-like growth factor-binding protein 3 (IGFBP-3) is a 264-amino acid peptide (molecular weight 29 kDa) produced by the liver. It is the most abundant of a group of IGFBPs that transport and control bioavailability and half-life of the insulin-like growth factors (IGF), in particular IGF-1, the major mediator of the anabolic- and growth ...

2020年5月4日 · Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent as well as in an IGF-independent manner.

IGFBP3 作为I型糖尿病（T1DM）的生物标志物已被广泛研究。 在T1DM患者中，不同人群血清的IGFBP3水平明显下降。 IGFBP3与HbA1c、总胆固醇和低密度脂蛋白胆固醇水平相关，与血压成反比，因此也可作为T1DM严重性标志物。 此外，患有自体免疫性甲状腺炎和乳糜泻的病人血清中IGFBP3的浓度明显较低。 更有趣的是，糖尿病患者眼泪中的IGFBP3水平明显增加，表明对糖尿病眼部并发症的发病机制有潜在贡献。 在新发糖尿病儿童中，血清IGFBP1可作为T1DM和 …

IGFBP-3 can either trigger the activation of IGF-dependent signaling, owing to its ability to transport IGF1/2, or can perform distinct biological cause effects independent of the IGF axis. The list of IGF-independent roles for IGFBP-3 is increasing with time.

igfbp-3 检测价值 胰岛素样生长因子结合蛋白-3与生长激素关系密切，是筛查生长激素缺乏症有的良好指标，被用来监测5岁以内的生长激素缺乏的情况；当胰岛素样生长因子结合蛋白-3增加时，对肢端肥大症有一定提示作用；胰岛素样生长因子结合蛋白-3水平降低则 ...

The IGFBPs, of which IGFBP-3 is the most abundant in postnatal blood, link with IGFs and prevent them from being degraded; they also facilitate IGF transport through body compartments. The interaction between IGFs and their specific receptors is partly regulated by structural modifications inherent to the IGFBPs.