Immunoglobulin superfamily - Wikipedia
Most Ig domains are either variable (IgV) or constant (IgC). IgV: IgV domains with 9 beta strands are generally longer than IgC domains with 7 beta strands. IgC1 and IgC2: Ig domains of …
免疫球蛋白超家族- 生物百科 - 生物行
根据IGSF结构域中Ig折叠方式、两个半胱氨酸之间氨基酸残基的数目以及IgV区或C区同源性的程度，IGSF结构域可分为V组、C1组和C2组。 1.V组 V组结构域的两个半胱氨酸之间含有氨基酸 …
On Origin and Evolution of the Antibody Molecule - PMC
IgV can be distinguished from IgC domains by the high sequence variability required for antigen recognition and by the presence of two extra strands (C′ and C″) located in the middle of the …
免疫球蛋白[Ig]超家族的结构和功能特点 - 丁香通研选
2013年8月19日 · 根据IGSF结构域中Ig折叠方式、两个半胱氨酸之间氨基酸残基的数目以及IgV区或C区同源性的程度，IGSF结构域可分为V组、C1组和C2组。 1.V组 V组结构域的两个半胱氨酸 …
The B7 family of immune-regulatory ligands - PMC - PubMed …
2005年6月6日 · The seven known members of the B7 family - B7.1, B7.2, ICOS-L, PD-L1, PD-L.2, B7-H3, and B7-H4 - are all transmembrane or glycosylphosphatidylinositol (GPI)-linked …
PD-1——重要的免疫检查点 - 知乎 - 知乎专栏
胞膜外区有1个免疫球蛋白恒定区(igc)结构域和1个免疫球蛋白可变区(igv)结构域。pd-l1细胞质区含有一个蛋白激酶c磷酸化位点，但胞内区的信号转导基序目前尚不明确。 3.1.2 pd-l1的表达 …
Towards a structural and functional analysis of the …
2024年1月1日 · IgV and IgC domains differ in their structural topology and the number of β strands they contain. Typically, IgV domains consist of nine β strands, with four (A, B, E, and …
CDD Conserved Protein Domain Family: IgV - National Center …
2021年10月25日 · The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic …
2017年4月6日 · Although there is a great diversity within this superfamily, based on the number of strands and sequence length, three principal classes of IgSF domains have been defined: the …
CD80 and CD86 IgC domains are important for quaternary …
CD86 and CD80, the ligands for the co-stimulatory molecules CD28 and CTLA-4, are members of the Ig superfamily. Their structure includes Ig variable-like (IgV) domains, Ig constant-like (IgC) …