Mar 30, 2025 · IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include Immunodeficiency 106 Viral Infections and Primary …

Nov 23, 2021 · Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 …

Nov 23, 2021 · Type I interferons form a complex with the receptor subunits IFNAR1 and IFNAR2, which stimulates cross-activation of the tyrosine kinases associated with the receptor subunits, …

Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping. Association of IFNAR1 and IFNAR2 with COVID-19 severity. …

IFNAR1 is S-palmitoylated on the PM proximal Cys 463 residue. IFNAR1 cytosolic tail interacts with TYK2 kinase FERM and SH2 domains through a minimal region that corresponds to …

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is …

Jan 5, 2025 · Title: CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

Mar 5, 2024 · Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with …

Sep 16, 2022 · The IFNAR1 gene encodes a membrane protein that, together with IFNAR2 (602376), forms the type I alpha/beta IFN receptor. Activation of the IFNAR by IFN-alpha and …

In this study, we have elucidated the in vivo immunomodulatory role of type I interferon signaling in T cells during experimental autoimmune encephalomyelitis by use of a novel transgenic …