IFNAR1结合I型IFN后，可激活对调节生长、存活、分化、病原体抗性和抗病毒免疫至关重要的 JAK-STAT信号通路，触发许多蛋白质的酪氨酸磷酸化，包括JAK、TYK2、STAT蛋白质等。 可以自身形成活性IFNB1受体，并激活不涉及JAK-STAT途径激活的信号级联（通过相似性）。 图1. 由I型IFN激活的经典Jak/STAT信号通路。 IFNAR1相关的Tyk2和IFNAR2相关的Jak1磷酸化STAT2和STAT1，与IRF9一起形成ISGF3复合物。 该复合物转运至细胞核，并与顺式元件ISRE（Ifn …

2025年3月30日 · IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include Immunodeficiency 106 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Overview of interferons-mediated signaling pathway and SARS-CoV-2 Infection.

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. [5][6] The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda.

IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1, and the high affinity subunit, IFNAR2. [7][8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway, along with MAPK, PI3K, and Akt signaling pathways. [2] .

IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor (IFN-α/β receptor) with IFNAR2. IFNAR1 interacts with tyrosine kinase 2 (Tyk2), and the interaction is able to stabilize IFNAR1 on the plasma membrane [1].

2021年11月23日 · Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively. Ligand binding results in the cross-phosphorylation of TYK2 and JAK1, which then phosphorylate tyrosine …

2021年11月23日 · Type I interferons form a complex with the receptor subunits IFNAR1 and IFNAR2, which stimulates cross-activation of the tyrosine kinases associated with the receptor subunits, TYK2 and JAK1. This leads to tyrosine phosphorylation of the IFNARs and of the STAT proteins that mediate transcriptional responses.

IFNAR1 signaling underlies an increased risk of tuberculosis in humans and reveals a function for the IFNAR1 inter-domain region in cytokine-cytokine receptor interaction and signal transduction.

IFNAR1的作用机制主要是与IFNAR2亚单位形成异二聚体受体，与干扰素α和β结合后，激活Janus激酶 (JAK)，进而激活信号转导及转录激活因子 (STAT)信号通路，尤其是通过磷酸化STAT1和STAT2，形成ISGF3复合体，促进干扰素刺激基因 (ISGs)的表达。 在生物学意义上，IFNAR1在机体的抗病毒反应和免疫调节中发挥关键作用。 它不仅参与了对病毒感染的防御机制，还与肿瘤免疫、自身免疫性疾病的发生发展有关。 例如，IFNAR1介导的信号通路可以增 …

In this study, we have elucidated the in vivo immunomodulatory role of type I interferon signaling in T cells during experimental autoimmune encephalomyelitis by use of a novel transgenic mouse, carrying a cd2 – ifnar1 transgene on a interferon-α/β receptor 1 null genetic background, thus allowing expression of the interferon-α/β receptor 1 and ...