The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human type I IFNs include many subtypes, such as interferons-α, -β, -ε, -κ, -ω, and -ζ.

干扰素 （interferon, IFN）是一组天然存在的细胞因子，最初是以其干扰细胞病毒复制的能力而得名。 干扰素具有重要的免疫调节、抗病毒、抗血管生成、抗增殖和抗肿瘤活性。 根据不同干扰素所传递信号的受体不同，通常将干扰素分为3个主要类型：Ⅰ型干扰素、Ⅱ型干扰素和Ⅲ型干扰素。 Ⅰ型干扰素是目前临床上抗病毒治疗的主力，也是最常用的一类抗生素。 IFN和靶细胞上的受体结合介导其生物学效应。 I型干扰素的受体由IFNAR1和IFNAR2两个亚单位组成。 IFNAR1结 …

人I型干扰素受体基因定位于第21号染色体上，分布于细胞表面，至少含有两个亚单位，命名为α（IFNAR1）和β（IFNAR2），它们属于II类细胞因子受体家族。 α亚单位只有一种形式，而β亚单位有可溶和跨膜两种形式。 IFNAR2（β亚单）有三种由相同基因选择性剪接产生的类型：IFNAR2a（βs短型体）、IFNAR2b（β可溶体）和IFNAR2c（βL长型体）。 βs短型体和βL长型体通过胞外和跨膜区域以及胞浆区域的第一个16氨基酸来区分。 可溶型由236氨基酸后面插入 …

The interferon-α/β receptor (IFNAR) is composed of two subunits, IFNAR1 and IFNAR2, encoding transmembrane polypeptides. Type I interferons (IFNs) bind IFNAR receptors and activate JAK kinases and STAT transcription factors to stimulate the transcription of genes downstream from IFN-stimulated response elements.

2025年3月30日 · IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1) is a Protein Coding gene. Diseases associated with IFNAR1 include Immunodeficiency 106 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Overview of interferons-mediated signaling pathway and SARS-CoV-2 Infection.

干扰素γ（IFNγ）是一种二聚体可溶性细胞因子，是II型干扰素的唯一成员。 这种干扰素的存在，在其历史的早期被称为免疫干扰素，被EF Wheelock描述为被植物血凝素刺激的人白细胞的产物，而被其他人描述为抗原刺激的淋巴细胞的产物。 在人类中，IFNγ蛋白由IFNG基因编码。

2013年12月23日 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage and...

2021年11月23日 · We suggest that tyrosine phosphorylation on IFNAR2-ICD drives the dissociation of phosphorylated STATs, thus maintaining high signaling flux. Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and JAK1, respectively.

2021年11月23日 · Type I interferons form a complex with the receptor subunits IFNAR1 and IFNAR2, which stimulates cross-activation of the tyrosine kinases associated with the receptor subunits, TYK2 and JAK1. This leads to tyrosine phosphorylation of the IFNARs and of the STAT proteins that mediate transcriptional responses.

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simply control subunits availability at the plasma membrane, an ...