干扰素刺激基因的抗病毒机制
2018年3月1日 · 此外，Mx1不仅能够通过抑制病毒核酸进入胞内来拮抗病毒，还能够通过调节IRF3的磷酸化来反向调节胞内IFNs的产生 [12]。 该家族另一成员Mx2蛋白，存在于细胞核内 …
MX1 - Wikipedia
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. [5][6] In mice, the interferon -inducible Mx protein is responsible for a specific antiviral …
MX1 Gene - GeneCards | MX1 Protein | MX1 Antibody
2025年3月30日 · MX1 (MX Dynamin Like GTPase 1) is a Protein Coding gene. Diseases associated with MX1 include Influenza and Rabies. Among its related pathways are Antiviral …
Myeloid cell interferon responses correlate with clearance of
2022年2月3日 · MX1 encodes a guanosine triphosphate (GTP)-metabolizing protein called IFN-induced GTP-binding protein Mx1 which is induced by Type I and Type II IFNs, antagonizes …
Mx 有一个大的N 端GTPase 结构域、一个 CID 结构域和C 端LZ 结构域，病毒入侵机体后激发 干扰素应答，而MX1 基因由干扰素刺激应答元件 (IFN-stimulated response element ，ISRE)诱 …
Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited
The IFN inducibility of the Mx1 gene facilitated the isolation of the Mx1 protein by comparison of the proteins derived from in vitro -translated mRNAs isolated from mouse strains that are …
ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN …
Both IFN-α/β and IFN-λ can induce the expression of Mx1, which is a primary restriction factor for influenza virus infection in mice (Mordstein et al., 2010).
Mx1-ing it up—Mitochondrial relay for interferon-dependent ...
2024年11月12日 · Chronic IFN-I production in autoimmune pathologies is driven by the release of mitochondrial RNA (mtRNA) and mitochondrial DNA (mtDNA) in response to mitochondrial …
MX1蛋白干扰素诱导实验详细解析 - 百家号
2024年9月9日 · 本文将详细介绍如何通过细胞模型进行干扰素刺激，并使用qPCR、Western. blot等技术检测MX1的表达水平，分析干扰素诱导MX1表达的机制和效应。 1. 实验设计. 扰素 …
Interferon-inducible Mx1 protein is highly expressed in renal …
Mx1 expression in renal specimens from 18 patients with lupus nephritis (LN), 18 with IgAN and 10 with AAV were evaluated using immunohistochemistry. Results: Mx1 protein concentrations …