2018年3月1日 · Interferons (IFNs) can induce the expression of a series of interferon-stimulated genes (ISGs). As direct-acting antiviral factors, ISGs play important roles in host antiviral defense. More and more studies reveal that ISGs directly or indirectly target multiple steps of …

An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1] [2] Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell. This interaction leads to the expression of a subset of genes involved in the innate immune system response. [1]

ifn-γ受体（ifngr）在刺激stat1时可能具有强音活性，从而导致低水平的干扰素刺激基因（isg）表达。 该体内平衡程序平衡了免疫激活和免疫抑制。 在癌症中，高水平的IFN-γ会刺激参与免疫激活的ISG，从而抑制肿瘤的生长。

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to …

2019年9月29日 · IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately 10% of the genes in the human genome have the potential to be regulated by IFNs. What do all of these genes do? It is a complex question without a simple answer.

2013年12月23日 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage and...

ifn priming是指小剂量的ifn-β就可以维持高水平的stat1/2 和 irf9，从而使免疫细胞在激活ifn信号时可以快速响应。在一些特殊的细胞类型中，i型干扰素也可以激活一些别的stat家族成员（如stat3, 4, 5a/5b,和 6）。

IFN（干扰素）是抵御病毒感染的第一道防线中的强效细胞因子和关键组分 1，主要通过直接诱导可抑制病毒复制的抗病原体分子对抗措施实现炎症和免疫控制 2。 参与抗病毒感染的 IFN 有三种类型（I 型、II 型和 III 型）。 I 型和 III 型 IFN 由免疫和组织特异性细胞表达，对病毒感染做出响应，两者共享重要抗病毒特性 2,3。 在经典通路中，I 型和 II 型 IFN 与其各自的受体 IFNAR1/2 和 IFNR1/IL10R2 相互作用，诱导构象变化，从而活化与受体相关的 JAK（Janus 激酶）家 …

2011年12月1日 · IFN induces a diverse range of antiviral effectors. Each virus has a unique, but partially overlapping, antiviral ‘ISG profile’. IFN effectors target multiple stages in the virus life cycle. The IFN signaling pathway is highly self-reinforcing. Viruses may hijack IFN effectors to promote replication.

2024年9月20日 · Non-canonical ISG induction provides a rapid, IFN-independent antiviral response, crucial for early defense against viral infections. This pathway operates quickly, often within specific cell types or in response to particular viruses, offering an immediate defense that buys time for the broader IFN-mediated defenses to take effect.