Jan 23, 2015 · Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the...

Dec 23, 2013 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage and preventing autoimmunity.

Type I IFNs elicit antiviral, antiproliferative and immunomodulatory responses by binding to the type I interferon receptor. The receptor consists of the IFNAR1 and IFNAR2 transmembrane proteins, and two associated cytoplasmic tyrosine kinases, the Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2).

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I.

Dec 23, 2023 · Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and periodontitis, impacting people's health and quality of life.

Jan 6, 2012 · Interferons (IFNs) are widely expressed cytokines with strong antiviral properties. There are three main types of IFNs: type I IFNs, type II IFN and type III IFNs. In addition to their role in...

IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ.

May 7, 2024 · Type I interferons (IFN-I) represent a group of pleiotropic cytokines renowned for their antiviral activity and immune regulatory functions. A multitude of studies have unveiled a critical role of IFN-I in the brain, influencing various neurological processes and diseases.

Nov 8, 2022 · IFN-Is are potent pro-inflammatory cytokines that are essential for fighting against viral infections (Taft and Bogunovic, 2018).

Mar 30, 2025 · IFN1@ (Interferon, Type 1, Cluster) is a Gene Cluster. Diseases associated with IFN1@ include Retinal Vasculitis and Rabies. Among its related pathways are Cytokines and inflammatory response and SARS-CoV-2 innate immunity evasion and cell-specific immune response. VectorBuilder Custom and pre-made pooled libraries (ie. CRISPR, shRNA, barcode)