Oct 3, 2010 · Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing …

Nov 4, 2019 · IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates …

Mar 30, 2025 · IFI16 (Interferon Gamma Inducible Protein 16) is a Protein Coding gene. Diseases associated with IFI16 include Herpes Simplex and Retinoblastoma. Among its related …

May 1, 2024 · Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, …

Feb 10, 2017 · Here, we show that IFI16 functions in the cGAS-STING pathway on two distinct levels. Depletion of IFI16 in macrophages impairs cGAMP production on DNA stimulation, …

The response, depending upon the cell-type and the extent of DNA-damage, ultimately results in cell death or cellular senescence. DDR-induced signaling in cells activates the ATM-p53 and …

Interferon-gamma inducible factor 16 (IFI16) restricts adeno-associated virus type 2 (AAV2) transduction in an immune-modulatory independent way. IFI16 Positively Regulates RIG-I …

IFI16 binding to viral DNA initiates LLPS and induction of cytokines during herpes simplex virus type 1 (HSV-1) infection. Multiple phosphorylation sites within an intrinsically disordered region …

Jul 21, 2023 · The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA, initiating innate immune signaling and suppressing viral transcription. …

Dec 1, 2014 · We propose that IFI16 plays a central role in the close interaction between the innate immune system and cellular regulation of the genome. 1. Introduction. The innate …