2010年10月3日 · Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs.

2019年11月4日 · IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor.

2025年3月30日 · IFI16 (Interferon Gamma Inducible Protein 16) is a Protein Coding gene. Diseases associated with IFI16 include Herpes Simplex and Retinoblastoma. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System.

2024年5月1日 · Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis,...

2017年2月10日 · Here, we show that IFI16 functions in the cGAS-STING pathway on two distinct levels. Depletion of IFI16 in macrophages impairs cGAMP production on DNA stimulation, whereas overexpression of IFI16...

The response, depending upon the cell-type and the extent of DNA-damage, ultimately results in cell death or cellular senescence. DDR-induced signaling in cells activates the ATM-p53 and ATM-IKKα/β-interferon (IFN)-β signaling pathways, thus leading to an induction of the p53 and IFN-inducible IFI16 gene.

Interferon-gamma inducible factor 16 (IFI16) restricts adeno-associated virus type 2 (AAV2) transduction in an immune-modulatory independent way. IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner.

IFI16 binding to viral DNA initiates LLPS and induction of cytokines during herpes simplex virus type 1 (HSV-1) infection. Multiple phosphorylation sites within an intrinsically disordered region (IDR) function combinatorially to activate IFI16 LLPS, facilitating filamentation.

2023年7月21日 · The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA, initiating innate immune signaling and suppressing viral transcription. However, little is known about mechanisms that initiate IFI16 antiviral functions or its regulation within the host DNA-filled nucleus. …

2014年12月1日 · We propose that IFI16 plays a central role in the close interaction between the innate immune system and cellular regulation of the genome. 1. Introduction. The innate immune system detects infections and damaged self to induce protective and inflammatory responses.