2018年12月10日 · Liquid–liquid phase separation (LLPS) of proteins containing intrinsically disordered regions (IDRs) has been proposed as a mechanism underlying the formation of...

近日Simon Alberti, Amy Gladfelter, 和 Tanja Mittag联合在 Cell 杂志发表了题为： Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates 的文章，较为系统地阐述了LLPS相关的理论基础，提出了LLPS的体内体外的实验设计方法的具体指南。

2020年12月11日 · Intrinsically disordered protein regions (IDRs) - regions that do not fold into a fixed three-dimensional structure but instead exist in a heterogeneous ensemble of conformations - have recently entered mainstream cell biology in the context of liquid-liquid phase separation (LLPS). IDRs are frequen …

2024年2月5日 · To simplify the identification of polypeptide sequences that are orthogonal to one another with respect to LLPS, we expressed pairs of IDRs and full-length (FL) proteins in a cellular context...

We achieve this advance by driving optogenetic TFs to undergo liquid-liquid phase separation (LLPS) and to form TF droplets around their target promoters. Eukaryotic cells are highly compartmentalized into specific organelles, which are either membrane enclosed or …

2022年8月12日 · Peptides are promising candidates for artificial LLPS-regulators because of their ability to potentially bind to IDRs complementarily. In this study, we provide a rational peptide design...

2021年8月2日，苏州大学生物医学研究所的周芳芳教授和浙江大学生命科学研究所张龙教授在影响因子18.187分的 Signal Transduction and Targeted Therapy 杂志上发表了题为《Liquid-liquid phase separation in human health and diseases》的综述，系统性地为我们介绍了 液相分离 在人类生理状态和疾病状态下的功能作用。 为了帮助大家更好的吸收综述的内容，我在阅读综述的时候，也给大家翻译了遍，希望能给大家带来有真正价值的“学术营养”。

2022年12月16日 · Liquid–liquid phase separation (LLPS) compartmentalizes kinases, substrates, and cofactors to promote substrate selectivity and spatiotemporal control of signaling events. Some kinases can act as scaffolds for phase separation, whereas others act as clients that depend on the LLPS properties of scaffolds.

2020年11月17日 · Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation (LLPS) of proteins, we conducted multiple-chain simulations of the N-terminal intrinsically disordered region (IDR) of DEAD-box helicase Ddx4, as …

2021年8月2日，苏州大学生物医学研究所的周芳芳教授和浙江大学生命科学研究所张龙教授在影响因子18.187分的Signal Transduction and Targeted Therapy杂志上发表了题为《Liquid-liquid phase separation in human health and diseases》的综述，系统性地介绍了液相分离在人类生理状态和疾病状态下的功能作用。 为了帮助大家更好的吸收综述的内容，葫芦娃本娃在阅读综述的时候，也给大家翻译了遍，希望能给大家带来有真正价值的“学术营养”。 摘要.