经典重读丨Nature肿瘤中IDH1突变和2-HG - 知乎专栏
2023年5月15日 · 研究发现突变的IDH1具有了新的催化能力，即依赖NAPDH催化α-酮戊二酸生成R-2-羟基戊二酸（2-HG）。 晶体结构研究表明活性位点132号位的精氨酸突变成组氨酸后导致 …
IDH1-mutant metabolite D-2-hydroxyglutarate inhibits ... - Nature
2024年7月9日 · IDH1-mutant gliomas elevate D-2-hydroxyglutarate (D-2HG) levels, with potential dual effects on tumor progression. Limited research has explored the potential...
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
2009年11月22日 · Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a...
The implications of IDH mutations for cancer development and …
2021年6月15日 · Mutations in IDH1 or IDH2 are frequent among several cancer types with various tissues of origin; the resultant mutated enzymes have neomorphic activity that leads to …
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and …
2024年5月17日 · Rather than simply losing its enzymatic activity, the IDH1 mutation imparts the enzyme with a neomorphic activity, leading to the reduction of α-ketoglutarate to the …
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and
2024年5月17日 · (R)-2-hydroxyglutarate ( (R)-2HG) treatment up-regulated the expression of miR-182-5p, enhanced glioma cell proliferation, and suppressed apoptosis; miR-182-5p …
Catalytically distinct metabolic enzyme isocitrate dehydrogenase 1 ...
Mutations in isocitrate dehydrogenase 1 (IDH1) impart a neomorphic reaction that produces D-2-hydroxyglutarate (D2HG), which can inhibit DNA demethylases to drive tumorigenesis. …
Artificial Intelligent-Enhanced Metabolite Profiling for …
6 天之前 · However, their limitations include high equipment costs, difficulty distinguishing D-2HG from its chiral enantiomer, and inability to spatially and quantitatively access the IDH1 …
IDH突变、表观遗传与靶向治疗 - 知乎
2013年，Agios公司的科学家利用高通量筛选发现了IDH1 R132H突变体抑制剂AGI-5198，该化合物能够降低脑胶质瘤细胞内2HG水平，促进组蛋白H3K9me3去甲基化，诱导肿瘤细胞分化， …
【学术前沿】清华大学沈晓骅团队揭示代谢酶IDH1微调控蛋白翻译 …
研究表明，代谢酶IDH1的错义突变使其获得新的酶活性将a-KG继续催化为羟戊二酸（2-hydroxyglutarate，2HG）。 此代谢产物抑制细胞内a-KG依赖的过氧化酶活性，使细胞内甲基 …