Toll-like Receptors and Inflammatory Bowel Disease - PMC
For TLR5, the relationship is closely linked to IBD. As a kind of transmembrane innate receptor, TLR5 distribution is polarized; in the colon, it is expressed on basolateral surfaces of gut …
Role of toll-like receptors in inflammatory bowel disease
2018年3月1日 · IECs of normal mucosa constitutively express TLR2, TLR3, TLR4 and TLR5 and their expression is altered in patients with IBD. For instance, TLR4 and TLR2 are extensively …
TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
In this review, we provided an overview of TLR5 about its role and potential mechanisms under the circumstances of intestinal homeostasis or inflammation to further explain the occurrence …
Toll-like Receptors and Inflammatory Bowel Disease - PubMed
2018年1月30日 · Increasing evidence has recently highlighted immune-system dysfunction, especially toll-like receptors (TLRs)-mediated innate immune dysfunction, as central players in …
Epithelial Toll-like receptors and their role in gut ... - Nature
2020年2月26日 · In this Review, we focus on the expression, regulation and functions of Toll-like receptors (TLRs) in the different intestinal epithelial lineages to analyse how epithelial …
TLR5 信号传导在肠粘膜免疫调节中的作用,Journal of Inflammation …
2023年6月14日 · 摘要：Toll 样受体 5 (TLR5) 是一种模式识别受体，可特异性识别鞭毛蛋白，因此通过激活先天性和适应性免疫反应在控制肠道稳态中发挥至关重要的作用。
Toll-like receptors in inflammatory bowel diseases: A decade …
2010年4月12日 · Recent findings in diverse murine models of colitis have helped to reveal the mechanistic importance of TLR dysfunction in IBD pathogenesis. It has become evident that …
Toll-like receptor 5 deficiency protects from wasting disease in a …
Background: Toll-like receptor 5 (TLR5) is implicated in the innate and adaptive immune responses that are associated with inflammatory bowel disease (IBD). In humans TLR5 is …
The intestinal barrier: a pivotal role in health, inflammation, and ...
2025年3月11日 · In the human small intestine, TLR4 and TLR5 are expressed on the basolateral surfaces of villus enterocytes, whereas TLR4 is also expressed in Paneth cells. Furthermore, …
Roseburia intestinalis stimulates TLR5-dependent intestinal …
We detected Toll-like receptor 2 (TLR2), TLR4, and TLR5 expression in Roseburia intestinalis (R. intestinalis)-treated mice with 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis.