近期，一篇发表于 Cell Death & Disease 的文章阐述了热休克蛋白 90（HSP90 ）作为多种 程序性细胞死亡 （PCD）常见调控节点的可能性，为众多疾病的治疗贡献了新视角。

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a …

2017年4月21日 · The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells.

HSP90 proteins take part in essential cellular processes and regulatory pathways like apoptosis, cell cycle control, cell viability, protein folding and degradation, and signalling events. In …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling …

2023年7月31日 · We discuss how these HSP90 forms are shaped by post-translational modifications (PTMs), co-chaperones and other factors, and present evidence for HSP90 …

自20世纪90年代首个hsp90抑制剂启动临床研究以来，尽管各大制药公司倾注了巨大的热情和资源，历经三十载的不懈努力，近三十余种的hsp90抑制剂相继进入临床试验阶段。

2018年8月29日 · The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular …

The cytosolic P. falciparum Hsp90 (PfHsp90) is a pivotal player in the development of the parasite, particularly during its intra-erythrocytic stage within the human host. 99 Protozoans, …

2019年10月6日 · hsp90 与 hsp90 的主要区别在于 hsp90的氨基酸端具有五倍序列（QTQDQ），但 hsp90 没有这样的序列[3] 。 热休克蛋白 hsp90（诱导型）在热诱导后显著 …